| Date | Location | Result | |
| Nov 13, 2021 | San Antonio, Texas | Trinity (TX) 1, Hardin-Simmons 0 | Box score |
| Nov 07, 2021 | Abilene, Texas | Mary Hardin-Baylor 0, Hardin-Simmons 0 (2OT) | Box score |
| Nov 05, 2021 | Abilene, Texas | Mary Hardin-Baylor 1, Concordia Texas 0 | Box score |
| Nov 05, 2021 | Abilene, Texas | Hardin-Simmons 4, McMurry 0 | Box score |
| Nov 02, 2021 | Round Rock, Texas | Concordia Texas 2, East Texas Baptist 0 | Box score |
| Nov 02, 2021 | Belton, Texas | Mary Hardin-Baylor 1, Belhaven 0 | Box score |
| Nov 02, 2021 | Abilene, Texas | Howard Payne 0, McMurry 0 (2OT) | Box score |
| Nov 02, 2021 | Abilene, Texas, UNIT | Hardin-Simmons 4, UT Dallas 0 | Box score |
| Oct 30, 2021 | Longview, Texas | Sul Ross State 5, LeTourneau 1 | Box score |
| Oct 29, 2021 | Abilene, Texas | McMurry 1, Hardin-Simmons 0 | Box score |
| Oct 29, 2021 | Longview, Texas | East Texas Baptist 1, LeTourneau 0 | Box score |
| Oct 29, 2021 | Belton, Texas | Mary Hardin-Baylor 4, Concordia Texas 1 | Box score |
| Oct 29, 2021 | Jackson, Miss. | Belhaven 4, MUW 0 | Box score |
| Oct 29, 2021 | Richardson, Texas | UT Dallas 3, Ozarks 0 | Box score |
| Oct 29, 2021 | Brownwood, Texas | Howard Payne 3, Sul Ross State 2 | Box score |
| Oct 27, 2021 | Conway, Ark. | Hendrix 1, Belhaven 0 | Box score |
| Oct 23, 2021 | Belton, UNITED STATE | Hardin-Simmons 1, Mary Hardin-Baylor 0 (2OT) | Box score |
| Oct 23, 2021 | Jackson, Miss. | Belhaven 2, UT Dallas 1 | Box score |
| Oct 23, 2021 | Brownwood, Texas | Howard Payne 4, LeTourneau 1 | Box score |
| Oct 23, 2021 | Round Rock, Texas | Concordia Texas 1, McMurry 0 | Box score |
| Oct 23, 2021 | Alpine, Texas | East Texas Baptist 2, Sul Ross State 0 | Box score |
| Oct 23, 2021 | Columbus, Miss. | Ozarks 5, MUW 0 | Box score |
| Oct 22, 2021 | Alpine, Texas | LeTourneau 2, Sul Ross State 1 | Box score |
| Oct 21, 2021 | Belton, Texas | Mary Hardin-Baylor 2, McMurry 0 | Box score |
| Oct 21, 2021 | Round Rock, Texas | Hardin-Simmons 3, Concordia Texas 0 | Box score |
| Oct 21, 2021 | Jackson, Miss. | Belhaven 3, Ozarks 0 | Box score |
| Oct 21, 2021 | Brownwood, Texas | Howard Payne 4, East Texas Baptist 1 | Box score |
| Oct 17, 2021 | Round Rock, Texas | Concordia Texas 4, Dallas Christian 0 | Box score |
| Oct 16, 2021 | Marshall, Texas | East Texas Baptist 4, UT Dallas 3 (OT) | Box score |
| Oct 16, 2021 | Abilene, Texas | Hardin-Simmons 1, Howard Payne 0 | Box score |
| Oct 16, 2021 | Abilene, Texas | McMurry 2, Sul Ross State 1 | Box score |
| Oct 16, 2021 | Longview, Texas | Ozarks 0, LeTourneau 0 (2OT) | Box score |
| Oct 16, 2021 | Belton, Texas | Mary Hardin-Baylor 1, Belhaven 0 (OT) | Box score |
| Oct 14, 2021 | Longview, Texas | UT Dallas 4, LeTourneau 0 | Box score |
| Oct 14, 2021 | Marshall, Texas | Ozarks 0, East Texas Baptist 0 (2OT) | Box score |
| Oct 14, 2021 | Abilene, Texas | Hardin-Simmons 3, Sul Ross State 0 | Box score |
| Oct 14, 2021 | Round Rock, Texas | Concordia Texas 2, Belhaven 1 | Box score |
| Oct 14, 2021 | Abilene, Texas | McMurry 4, Howard Payne 0 | Box score |
| Oct 10, 2021 | Longview, Texas, UNI | LeTourneau 1, Centenary (LA) 0 (OT) | Box score |
| Oct 09, 2021 | Richardson, Texas | McMurry 4, UT Dallas 2 | Box score |
| Oct 09, 2021 | Jackson, Miss. | East Texas Baptist 1, Belhaven 0 | Box score |
| Oct 09, 2021 | Brownwood, Texas | Mary Hardin-Baylor 2, Howard Payne 2 (2OT) | Box score |
| Oct 09, 2021 | Clarksville, Ark. | Hardin-Simmons 3, Ozarks 0 | Box score |
| Oct 09, 2021 | Alpine, Texas | Concordia Texas 4, Sul Ross State 1 | Box score |
| Oct 07, 2021 | Richardson, Texas | Hardin-Simmons 2, UT Dallas 1 | Box score |
| Oct 07, 2021 | Jackson, Miss. | Belhaven 3, LeTourneau 1 | Box score |
| Oct 07, 2021 | Alpine, Texas | Mary Hardin-Baylor 7, Sul Ross State 0 | Box score |
| Oct 07, 2021 | Brownwood, Texas | Howard Payne 2, Concordia Texas 1 | Box score |
| Oct 07, 2021 | Clarksville, Ark. | McMurry 4, Ozarks 0 | Box score |
| Oct 03, 2021 | Abilene, Texas | Hardin-Simmons 3, East Texas Baptist 0 | Box score |
| Oct 03, 2021 | Abilene, Texas | McMurry 3, LeTourneau 0 | Box score |
| Oct 02, 2021 | Belton, Texas | Mary Hardin-Baylor 1, UT Dallas 0 | Box score |
| Oct 02, 2021 | Austin, Texas | Concordia Texas 2, Ozarks 1 | Box score |
| Oct 02, 2021 | Brownwood, Texas | Howard Payne 1, Belhaven 0 | Box score |
| Oct 01, 2021 | Abilene, Texas | East Texas Baptist 0, McMurry 0 (2OT) | Box score |
| Oct 01, 2021 | Abilene, Texas | Hardin-Simmons 6, LeTourneau 0 | Box score |
| Sep 30, 2021 | Belton, Texas | Mary Hardin-Baylor 8, Ozarks 0 | Box score |
| Sep 30, 2021 | Round Rock, Texas | Concordia Texas 2, UT Dallas 1 (2OT) | Box score |
| Sep 30, 2021 | Alpine, UNITED STATE | Belhaven 4, Sul Ross State 1 | Box score |
| Sep 25, 2021 | Richardson, Texas | UT Dallas 2, Howard Payne 0 | Box score |
| Sep 25, 2021 | Longview, Texas | Mary Hardin-Baylor 3, LeTourneau 1 | Box score |
| Sep 25, 2021 | Marshall, Texas | Concordia Texas 3, East Texas Baptist 2 | Box score |
| Sep 25, 2021 | Clarksville, Ark. | Ozarks 1, Sul Ross State 0 | Box score |
| Sep 25, 2021 | Jackson, Miss. | McMurry 2, Belhaven 2 (2OT) | Box score |
| Sep 23, 2021 | Richardson, Texas | UT Dallas 3, Sul Ross State 0 | Box score |
| Sep 23, 2021 | Longview, Texas | Concordia Texas 5, LeTourneau 1 | Box score |
| Sep 23, 2021 | Marshall, Texas | East Texas Baptist 2, Mary Hardin-Baylor 1 | Box score |
| Sep 23, 2021 | Jackson, Miss. | Hardin-Simmons 1, Belhaven 0 | Box score |
| Sep 23, 2021 | Clarksville, Ark. | Howard Payne 2, Ozarks 0 | Box score |
| Sep 21, 2021 | Jackson, Miss. | Belhaven 5, Austin 0 | Box score |
| Sep 19, 2021 | Shreveport, La. | UT Dallas 3, Centenary (LA) 0 | Box score |
| Sep 19, 2021 | Marshall, Texas | East Texas Baptist 2, Southwestern (TX) 0 | Box score |
| Sep 19, 2021 | Clarksville, Ark. | Dallas 1, Ozarks 0 | Box score |
| Sep 19, 2021 | Abilene, Texas | McMurry 2, Texas Lutheran 0 | Box score |
| Sep 18, 2021 | Abilene, Texas | Hardin-Simmons 6, UW-Stevens Point 0 | Box score |
| Sep 18, 2021 | Belton, Texas | Mary Hardin-Baylor 4, Austin 0 | Box score |
| Sep 18, 2021 | Sewanee, Tenn. | Maryville (TN) 1, LeTourneau 0 | Box score |
| Sep 18, 2021 | San Antonio, Texas, | Trinity (TX) 6, Howard Payne 0 | Box score |
| Sep 18, 2021 | Shreveport, La. | Belhaven 1, Schreiner 0 | Box score |
| Sep 17, 2021 | Belton, Texas | Mary Hardin-Baylor 3, UW-Stevens Point 0 | Box score |
| Sep 17, 2021 | Abilene, Texas | Hardin-Simmons 14, Arlington Baptist 0 | Box score |
| Sep 17, 2021 | Shreveport, La. | Belhaven 3, Centenary (LA) 0 | Box score |
| Sep 17, 2021 | Sewanee, Tenn. | Sewanee 4, LeTourneau 0 | Box score |
| Sep 17, 2021 | Irving, Texas | Concordia Texas 1, Dallas 0 | Box score |
| Sep 17, 2021 | Houston, Texas | East Texas Baptist 0, St. Thomas (TX) 0 (2OT) | Box score |
| Sep 17, 2021 | Shreveport, La. | UT Dallas 5, Schreiner 0 | Box score |
| Sep 17, 2021 | Brownwood, Texas | Howard Payne 5, Austin 1 | Box score |
| Sep 15, 2021 | Conway, Ark. | Hendrix 3, Ozarks 1 | Box score |
| Sep 14, 2021 | Bethany, Okla. | McMurry 3, Southern Nazarene 1 | Box score |
| Sep 12, 2021 | Richardson, Texas | UT Dallas 2, Pacific (OR) 0 | Box score |
| Sep 12, 2021 | Longview, Texas | Millsaps 2, LeTourneau 2 (2OT) | Box score |
| Sep 12, 2021 | San Antonio, Texas | Trinity (TX) 4, East Texas Baptist 1 | Box score |
| Sep 12, 2021 | Abilene, Texas | McMurry 5, TAMU-San Antonio 0 | Box score |
| Sep 12, 2021 | San Antonio, Texas | Cal Lutheran 2, Concordia Texas 1 | Box score |
| Sep 11, 2021 | Georgetown, Texas | Southwestern (TX) 1, Hardin-Simmons 0 | Box score |
| Sep 11, 2021 | Houston, Texas | Mary Hardin-Baylor 8, St. Thomas (TX) 0 | Box score |
| Sep 11, 2021 | Kerrville, Texas | Howard Payne 4, Schreiner 1 | Box score |
| Sep 11, 2021 | Jackson, Miss. | Huntingdon 2, Belhaven 1 | Box score |
| Sep 10, 2021 | Marshall, Texas | East Texas Baptist 4, Millsaps 0 | Box score |
| Sep 10, 2021 | Irving, Texas | Mary Hardin-Baylor 1, Dallas 0 | Box score |
| Sep 10, 2021 | Richardson, Texas | UT Dallas 4, Birmingham-Southern 0 | Box score |
| Sep 10, 2021 | Longview, Texas | LeTourneau 4, Jarvis Christian 1 | Box score |
| Sep 10, 2021 | Clarksville, Ark. | Ozarks 3, Austin 1 | Box score |
| Sep 10, 2021 | Kerrville, Texas | McMurry 4, Schreiner 0 | Box score |
| Sep 10, 2021 | Seguin, Texas | Texas Lutheran 2, Howard Payne 1 (2OT) | Box score |
| Sep 09, 2021 | Georgetown, Texas | Southwestern (TX) 1, McMurry 0 | Box score |
| Sep 09, 2021 | Clarksville, Texas | Hendrix 0, Ozarks 0 (2OT) | Box score |
| Sep 08, 2021 | Edinburg, Texas | UT Rio Grande Valley 4, Concordia Texas 0 | Box score |
| Sep 07, 2021 | Georgetown, Texas | Southwestern (TX) 1, Mary Hardin-Baylor 0 (OT) | Box score |
| Sep 07, 2021 | Montgomery, Ala. | Belhaven 1, Faulkner 0 | Box score |
| Sep 06, 2021 | Searcy, Ark. | Harding 5, Ozarks 0 | Box score |
| Sep 06, 2021 | Longview, Texas | Dallas 2, LeTourneau 0 | Box score |
| Sep 06, 2021 | Shreveport, La. | East Texas Baptist 3, Centenary (LA) 1 | Box score |
| Sep 06, 2021 | Brownwood, Texas | Howard Payne 3, Jarvis Christian 0 | Box score |
| Sep 05, 2021 | Richardson, Texas | UT Dallas 4, Austin 1 | Box score |
| Sep 05, 2021 | San Antonio, Texas | Trinity (TX) 4, Hardin-Simmons 1 | Box score |
| Sep 05, 2021 | Kerrville, Texas | Sul Ross St. 1, Schreiner 0 | Box score |
| Sep 05, 2021 | Abilene, Texas | McMurry 4, St. Thomas (TX) 0 | Box score |
| Sep 04, 2021 | Sherman, Texas | Austin 2, LeTourneau 1 | Box score |
| Sep 04, 2021 | Brownwood, Texas | Howard Payne 2, Paul Quinn 0 | Box score |
| Sep 04, 2021 | Jackson, Miss. | Belhaven 2, Birmingham-Southern 0 | Box score |
| Sep 03, 2021 | Abilene, Texas | Hardin-Simmons 5, St. Thomas (TX) 1 | Box score |
| Sep 03, 2021 | Richardson, Texas | UT Dallas 3, Dallas 2 (2OT) | Box score |
| Sep 03, 2021 | Georgetown, Texas | Southwestern (TX) 4, Sul Ross State 1 | Box score |
| Sep 03, 2021 | San Antonio, Texas | Trinity (TX) 3, McMurry 0 | Box score |
| Sep 03, 2021 | San Antonio, Texas | Our Lady of the Lake 4, Concordia Texas 0 | Box score |
| Sep 01, 2021 | Georgetown, Texas | Southwestern (TX) 2, UT Dallas 1 | Box score |
| Sep 01, 2021 | Belton, Texas | Mary Hardin-Baylor 3, Texas Lutheran 0 | Box score |
| Sep 01, 2021 | Marshall, Texas | East Texas Baptist 2, Hendrix 0 | Box score |
| Sep 01, 2021 | Round Rock, Texas | Houston-Victoria 3, Concordia Texas 2 | Box score |
| Sep 01, 2021 | Houston, Texas | Howard Payne 5, St. Thomas (TX) 4 | Box score |